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Non-aqueous Titration

Many organic pharmaceutical compounds are weak acids (e.g., acid halides, acid anhydrides, or carboxylic acids, etc.) or weak bases (e.g., amines, nitrogen-containing heterocyclic compounds, quartenary ammonium compounds, etc.) with limited solubility in water, which makes titration in conventional aqueous media difficult. Water-insoluble compounds acquire enhanced acidic or basic properties when dissolved in organic solvents, thereby allowing for an accurate, quantitative titration in non-aqueous media. Additionally, through the selection of the appropriate solvent, it may be possible to selectively titrate the portion of the compound that is of most interest. For more information on this service, please feel free to contact us.

When requesting titration analysis, please use our RML Analysis Request Form.